Category Archives: PI

Maren Friesen

FRIESEN_CV_CURRENT (as of Feb 2017).

I grew up in rural British Columbia and attended the University of British Columbia in Vancouver, with an exchange year at McGill University in Montreal. I was part of “Science One”, an amazing first year science program that stressed the interdisciplinary nature of science. As a result, I had a hard time choosing my major—I wanted to quadruple major in math, biology, biochemistry, and english with a minor in physics. I ended up with a double major in Honours Math and Ecology, with several literature and writing courses and research experience in the evolution of polyploidy with Sally Otto, air quality modeling and environmental microbiology at the National Research Center of Canada, and experimental evolution of E. coli with Michael Doebeli.

I was a member of the Population Biology graduate group at UC Davis, having selected UCD as a school with both excellent quantitative biologists and a highly diverse taxonomic breadth of study organisms. During my first year Field Ecology course, Don Strong excavated a Lupinus nanus plant and showed me the brilliantly pink nodules formed by rhizobium bacteria. It was love at first sight. My dissertation consisted of (i) mathematical modeling of the interaction to determine whether multiply infected nodules gave rise to the evolution of cheaters [they can, but only under limited circumstances and the cheating is rarely absolute], (ii) a meta-analysis of rhizobia-legume fitness correlations [overall, they are strongly positive both across mutants and natural strains], and (iii) experimental evolution of Sinorhizobium meliloti on its host, the model legume Medicago truncatula. I selected the Medicago-Sinorhizobium interaction to focus on as it is one of the best-studied mutualistic plant-microbe interactions at the molecular level.

During my PhD, my advisor Sergey Nuzhdin and I wrote a NSF Plant Genome grant to study the genomic basis of adaptation and co-adaptation in natural populations of Medicago truncatula that occur on and off saline soils in Tunisia. Sergey moved to the University of Southern California and I joined him for my my post-doc, which was funded by this grant. I developed my bioinformatic skills, going from raw Illumina files all the way through statistical analysis and biological interpretation, collaborated on a phenotype database that involved developing the Natural Diversity module of Chado within the GMOD ecosystem, and did field work in both Tunisia and Portugal.

My lab in Plant Biology at Michigan State University started in January 2013. We are pursuing a suite of projects looking at the evolutionary ecology of beneficial plant-microbe interactions with an emphasis on nitrogen-fixation, using a combination of molecular, greenhouse, and field approaches. Check out our funded projects in the categories to the right! In addition to running a lab full of amazing students, postdocs, and technicians, I also teach the undergraduate Evolution course (IBIO445) at MSU.

Follow my meeting tweets @symbiomics !